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Guías Clínicas Guía Práctica de la OMGE: Probióticos y prebióticos - F. Guarner et al. 7. Vanderhoof JA, Whitney DB, Antonson DL, Hanner TL, Lupo JV, Young RJ. Lactobacillus GG in the prevention of antibiotic-associated diarrhoea in children. J Pediatr 1999; 135: 564-8. 8. Correa NB, Peret Filho LA, Penna FJ, Lima FM, Nicoli JR. A randomized formula controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antibiotic-associated diarrhea in infants. J Clin Gastroenterol 2005; 39: 385-9. 9. Ruszczyński M, Radzikowski A, Szajewska H. Clinical trial: effectiveness of Lactobacillus rhamnosus (strains E/N, Oxy and Pen) in the prevention of antibiotic-associated diarrhoea in children. Aliment Pharmacol Ther 2008; 28: 154-61. 10. Szajewska H, Kotowska M, Mrukowicz JZ, Armanska M, Mikolajczyk W. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr 2001; 138: 361-5. 11. Hojsak I, Abdovińá S, Szajewska H, Milosevińá M, Krznarińá Z, Kolacek S. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics 2010; 125: e1171-7. 12. Saavedra JM, Bauman NA, Oung I, Perman JA, Yolken RH. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet 1994; 334: 1046-9. 13. Merenstein D, Murphy M, Fokar A, et al. Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study. Eur J Clin Nutr 2010; 64: 669-77. 14. Pedone CA, Arnaud CC, Postaire ER, Bouley CF, Reinert P. Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea. Int J Clin Pract 2000; 54: 568-71. 15. Pedone CA, Bernabeu AO, Postaire ER, Bouley CF, Reinert P. The effect of supplementation with milk fermented by Lactobacillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres. Int J Clin Pract 1999; 53: 179-84. 16. Weizman Z, Asli G, Alsheikh A. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics 2005; 115: 5-9. 17. Sur D, Manna B, Niyogi SK, et al. Role of probiotic in preventing acute diarrhoea in children: a community-based, randomized, double-blind placebo-controlled field trial in an urban slum. Epidemiol Infect 2011; 139: 919-26. 18. Sykora J, Valeckova K, Amlerova J, et al. Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study. J Clin Gastroenterol 2005; 39: 692-8. 19. Horvath A, Dziechciarz P, Szajewska H. Systematic review and meta-analysis of randomized controlled trials: Lactobacillus rhamnosus GG for abdominal pain-related functional gastrointestinal disorders in childhood. Aliment Pharmacol Ther 2011; 33: 1302-10. 20. Coccorullo P, Strisciuglio C, Martinelli M, Miele E, Greco L, Staiano A. Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a double-blind, randomized, placebo-controlled study. J Pediatrics 2010; 157: 598-602. 21. Romano C, Ferrau’ V, Cavataio F, et al. Lactobacillus reuteri in children with functional abdominal pain (FAP). J Paediatr Child Health 2010 Jul 8. [Epub ahead of print]. 22. Savino F, Cordisco L, Tarasco V, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics 2010; 126: e526-33. 23. Lin HC, Hsu CH, Chen HL, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics 2008; 122: 693-700. 24. Lin HC, Su BH, Chen AC, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics 2005; 115: 1-4. 25. Bin-Nun A, Bromiker R, Wilschanski M, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr 2005; 147: 192-6. 26. Deshpande G, Rao S, Patole S, Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics 2010; 125: 921-30. 27. Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A. Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol. 2009; 104: 437-43. 216 Tabla 9. Indicaciones basadas en la evidencia referentes al uso de probióticos y prebióticos en gastroenterología de adultos Trastorno, acción Cepa probiótica / prebiótica Dosis recomendada Nivel de evidencia Ref. Comentarios Tratamiento de la diarrea aguda en adultos Enterococcus faecium LAB SF68 108 ufc, tres veces al día 1b 1 Lactobacillus paracasei B 21060 109 ufc 2 veces al día 2b 2 o L. rhamnosus GG Saccharomyces. boulardii, cepa de S. cerevisiae 109ufc por cápsula de 50 mg, 2-6 cápsulas al día 1b 1, 3, 4 Prevención de la diarrea asociada a antibióticos en adultos E. faecium LAB SF68 108 ufc, 2 veces al día 1b 5 S. boulardii, cepa de S. cerevisiae 1 g o 4 × 109 ufc por día 1b 5 L. rhamnosus GG 1010–1011 ufc, 2 veces al día 1b 5 L. casei DN-114 001 en leche 1010 ufc, 2 veces al día 1b 6 fermentada Bacillus clausii (cepas de Enterogermina) 2 × 109 esporas, tres veces al día 1b 7 L. acidophilus CL1285 + L. casei LBC80R 5 × 1010 ufc, 1 ó 2 veces al día 1b 8, 9 Las cepas se administraron en cápsulas o en vehículos de leche fermentada Gastroenterol. latinoam 2012; Vol 23, Nº 4: 206-221


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